Introduction: Researchers from the EU Nova Project are at the forefront of developing advanced biological models to predict and mitigate potential side effects in next-generation antimicrobial coatings. This groundbreaking initiative aims to create safer, more effective antimicrobial solutions by addressing possible toxicological reactions during the material design phase.

Research Highlights: The team, led by Philipp Meier and comprising experts from institutions such as Empa-Swiss Federal Laboratories, the University of Ljubljana, and the Fraunhofer Institute, is focusing on several key areas:

• In Vitro Assays: These assays assess the biocompatibility and immunocompatibility of antimicrobial coatings used in long-term implantable biomaterials, such as hernia meshes.
• Visualization Techniques: Utilizing advanced methods like Focused Ion Beam-Scanning Electron Microscopy (FIB/SEM) to study the biological responses triggered by these nanomaterials.
• Ethical Research Practices: The project aims to complement existing ISO standards and OECD guidelines, promoting the reduction of animal testing by developing reliable in vitro models.

Significance: By predicting potential side effects early in the design process, the project not only ensures the safety and efficacy of antimicrobial coatings but also accelerates their development. This proactive approach aligns with ethical research practices and addresses the urgent need for innovative solutions to combat viral, bacterial, and fungal pandemics.

Conclusion: The EU Nova Project’s innovative methods represent a significant advancement in the field of nanomaterial safety assessment. The research has received funding from the European Union's Horizon Europe Framework Programme and support from various national bodies, underscoring its critical importance and impact.

 

You can take a look at the whole poster here. 

 

For more information, please contact Philipp Meier at Empa-Swiss Federal Laboratories.

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References:

• Chua MH, et al. (2020). Face Masks in the New COVID-19 Normal: Materials, Testing, and Perspectives. Research.
• Schmutz M, et al. (2020). Cotton and surgical masks—what ecological factors are relevant for their sustainability? Sustainability.
• Clinical Infectious Diseases. (2020). Detection of infectious influenza virus in cough aerosols generated in a simulated patient examination room.

Acknowledgment: This research is funded by the European Union's Horizon Europe Framework Programme under grant agreement No. 101058554 and co-funded by the Swiss State Secretariat for Education, Research and Innovation (SERI) and the UK Research and Innovation (UKRI).