WP5 aims to develop and use testing strategies that support coating invention and development activities and allows a predictive estimation of the antimicrobial action to be expected when they are deployed in practice.
To achieve objectives 1 and 2, the activities of participants 2 (Fraunhofer) and 12 (IMSL) will focus initially on supporting new coating invention and development by providing a harmonised testing programme to the participants of WP2. The cascade of testing and the model species to be employed will be selected during months 1 – 3 (bacteria, fungi and bacteriophages). The purpose of the screen will be to select coatings / coating technologies that can be progressed for further development.
Candidate systems will then be tested using conditions that reflect intended areas of use such that
coating / application / material matching can be achieved.
WP5 includes the following objectives:
- To provide a service that supports the invention and development of the novel antimicrobial surfaces by screening candidate systems for activity against a representative range of target species in a rapid manner that allows for robust
comparisons of relative efficacy to be made.
- To assess those candidates that have been selected for progress for activity under conditions that simulate better their intended use. Both assessment systems are intended to form part of a ‘feed-back loop’ to both inform on system design and help to optimise it and allow the development of claims that are realistic rather than aspirational.
- Extend the development of the models used for Objective 2 (and to a lesser extent, Objective 1) above to improve their compliance with the real-world conditions they are intended to reflect.
- Extend the simulations to encompass mammalian viruses as, although the models will be functionalised for bacteriophage surrogates of them, there are a number of technical (as well as logistical and economic) hurdles that, to date, have prevented this being done for mammalian species.
- To develop and use testing strategies that support coating invention and development activities and allows a predictive estimation of the antimicrobial action to be expected when they are deployed in practice.